Dr. Marla Shapiro: Does your job increase your risk of breast cancer?
Published Tuesday, November 20, 2012 7:55AM EST
Does your job increase your breast cancer risk?
Is there a link between the risk of breast cancer and the working environment?
Environmental Health provides further evidence on this previously neglected research topic, confirming that certain occupations do pose a higher risk of breast cancer than others, particularly those that expose workers to potential carcinogens and endocrine disrupters.
Breast cancer is the most frequent cancer diagnosis among women in industrialized countries, and North American rates are among the highest in the world.
Endocrine-disrupting chemicals and carcinogens, some of which may not have yet been classified as such, are present in many working environments and could increase breast cancer risk.
The study looked at the possible links between breast cancer and occupation, particularly in farming and manufacturing.
The population-based case-control study was conducted in Southern Ontario, Canada. It included 1006 breast cancer cases (referred by the Windsor Regional Cancer Centre), with 1147 randomly selected and matched community controls. The data also collected included the participants’ occupational and reproductive histories.
All jobs were coded for their likelihood of exposure to carcinogens and endocrine disruptors, and patients' tumor pathology regarding endocrine receptor status was assessed.
The study found that women in jobs with potentially high exposures to carcinogens and endocrine disrupters had an elevated breast cancer risk.
Sectors with increased risk included:
- Automotive plastics manufacturing
- Food canning and metal-working
Importantly, premenopausal breast cancer risk was highest in the automotive plastics and food canning industries.
The findings also suggested that women with lower socioeconomic status had an elevated risk of breast cancer, and may result from higher exposures to endocrine-disrupting chemicals in the lower-income manufacturing and agricultural industries of the study area.
The results lend weight to hypotheses linking breast cancer risk and exposures likely to include carcinogens and endocrine disrupters.
The results highlight the importance of occupational studies in identifying and quantifying environmental risk factors. It also illustrates the value of taking detailed occupational histories of cancer patients. Mounting evidence suggests that we need to re-evaluate occupational exposure limits in regulatory protection.